5 Best Pharmacies in Downtown, Charleston SC
Updated 11 October 2026 · 16 pharmacies in Downtown, Charleston SC considered · Ranked from Google ratings
This list covers pharmacies in the Downtown Charleston SC area for prescriptions, refills, over-the-counter items, and medication questions. Each business was ranked by its Google rating, weighted by how many people left a review, and 16 qualifying businesses were considered. Some listed pharmacies have addresses in nearby neighborhoods and suburbs, so check the address before you visit. Hours, services, and accessibility features come from each Google profile, and the review notes describe what past customers have said about their experience.
#1
Park Circle Pharmacy
★ 4.9 (105 Google reviews)Pharmacy
Representative photo, not of this business.
Park Circle Pharmacy on Spruill Avenue in North Charleston holds a 4.9 Google rating from 105 reviews. It is open weekdays from 9 am to 7 pm and Saturday from 10 am to 3 pm, and it is closed on Sundays. Listed services include delivery, curbside and in-store pickup, medication disposal, and walk-ins. Reviewers mention a consistent refill process, staff who answer texts directly, help with insurance and medication pricing, and a good selection of over-the-counter products.
Best for: Responsive staff and text-based refill help
- Address
- 4412 Spruill Ave Ste C, North Charleston, SC 29405, United States
- Hours
- Fri 9 am–7 pm; Mon 9 am–7 pm; Sat 10 am–3 pm; Sun Closed; Thu 9 am–7 pm; Tue 9 am–7 pm; Wed 9 am–7 pm
#2
Delta Pharmacy & Medical Supply
★ 4.9 (96 Google reviews)Pharmacy
Representative photo, not of this business.
Delta Pharmacy and Medical Supply on East Bay Street holds a 4.9 Google rating from 96 reviews. Hours are Monday through Friday from 9 am to 6 pm and Saturday from 9 am to 1 pm, with Sunday closed. Google lists wheelchair-accessible parking and entrance. Reviewers mention a friendly team that treats customers like patients, quick handling of prescriptions for complicated health needs, and staff who went out of their way during a difficult day. Several say they have relied on the pharmacy for years.
Best for: Long-term patients and medical supplies
- Address
- 346 E Bay St, Charleston, SC 29401, United States
- Hours
- Fri 9 am–6 pm; Mon 9 am–6 pm; Sat 9 am–1 pm; Sun Closed; Thu 9 am–6 pm; Tue 9 am–6 pm; Wed 9 am–6 pm
#3
Focus: Meds Pharmacy and Wellness
★ 4.9 (70 Google reviews)Pharmacy
Representative photo, not of this business.
Focus: Meds Pharmacy and Wellness on Sam Rittenberg Boulevard holds a 4.9 Google rating from 70 reviews. It is open weekdays from 9 am to 2 pm and 2:30 to 6:30 pm, with a midday break, and it is closed on weekends. Listed accessibility features include a wheelchair-accessible car park and entrance. Reviewers mention being greeted by name, fast refills, and a locally owned feel. Some praise the warmth of the staff and say they prefer it to large chain pharmacies.
Best for: Personal attention and fast refills
- Address
- 2000 Sam Rittenberg Blvd Ste 134, Charleston, SC 29407, United States
- Hours
- Fri 9 am–2 pm, 2:30–6:30 pm; Mon 9 am–2 pm, 2:30–6:30 pm; Sat Closed; Sun Closed; Thu 9 am–2 pm, 2:30–6:30 pm; Tue 9 am–2 pm, 2:30–6:30 pm; Wed 9 am–2 pm, 2:30–6:30 pm
#4
Pitt Street Pharmacy
★ 4.8 (91 Google reviews)Pharmacy
Representative photo, not of this business.
Pitt Street Pharmacy at 111 Pitt Street in Mt Pleasant holds a 4.8 Google rating from 91 reviews. Hours are 9 am to 6 pm Monday through Friday and 9 am to 2 pm on Saturday, with Sunday closed. Listed services include delivery, medication disposal, and quick visits, and card and mobile payments are accepted. Reviewers mention a private consultation about a hormone test and staff who explained options clearly. Others describe a store with an old-fashioned soda fountain and grill and a vintage feel.
Best for: Private consultations and a vintage soda fountain
- Address
- 111 Pitt St, Mt Pleasant, SC 29464, United States
- Hours
- Fri 9 am–6 pm; Mon 9 am–6 pm; Sat 9 am–2 pm; Sun Closed; Thu 9 am–6 pm; Tue 9 am–6 pm; Wed 9 am–6 pm
#5
Dottie's Pharmacy
★ 4.7 (120 Google reviews)Pharmacy
Representative photo, not of this business.
Dottie's Pharmacy on Folly Road holds a 4.7 Google rating from 120 reviews. It is open Monday through Friday from 9 am to 6 pm and Saturday from 9 am to 1 pm, and it is closed on Sundays. Google lists wheelchair-accessible parking and entrance. Reviewers mention a team that is knowledgeable and friendly, the same familiar faces on each visit, and attentive help for families with special needs. One reviewer compares it favorably with a nearby national chain pharmacy.
Best for: Family care and familiar faces
- Address
- 325 Folly Rd Ste 101, Charleston, SC 29412, United States
- Hours
- Fri 9 am–6 pm; Mon 9 am–6 pm; Sat 9 am–1 pm; Sun Closed; Thu 9 am–6 pm; Tue 9 am–6 pm; Wed 9 am–6 pm
How we made this list
We looked at 16 pharmacies in Downtown, Charleston SC with a Google rating of 4.0 or higher and at least 20 reviews, then ranked by Google rating, weighted by how many people left one. A rating from thousands of reviews counts for more than the same rating from a handful, so a new place with a few perfect scores does not jump the queue. Ratings and hours are from public Google listings on 11 October 2026 and can change. Nobody paid to be on this list.
Tips before you go
- For an early start, Park Circle Pharmacy opens at 9 am.
- Hours and prices come from Google listings and change, so check the listing before a long trip.
Frequently asked questions
Which is the highest-rated pharmacy on this list?
Park Circle Pharmacy ranks first, with a Google rating of 4.9 from 105 reviews. Delta Pharmacy & Medical Supply is second at 4.9 from 96 reviews.
Which pharmacies in Downtown, Charleston SC are open late?
None of these stays open past midnight. The latest to close is Park Circle Pharmacy, at 7 pm.
Which of these have free parking?
Google lists free parking for Park Circle Pharmacy.
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