5 Best Clinics in Downtown, Charleston SC
Updated 11 October 2026 · 27 clinics in Downtown, Charleston SC considered · Ranked from Google ratings
This guide lists five clinics in Downtown Charleston SC that a local or visitor might consider for urgent or primary care. Twenty-seven qualifying businesses were considered, and they were ranked by Google rating, weighted by how many people left a review. Each entry gives the clinic type, hours, address, listed services, and reviewer comments. Because hours and availability can change, check the business directly before visiting, especially for walk-in care or a same-day appointment.
#1
Access Urgent
★ 4.9 (879 Google reviews)Urgent care center
Representative photo, not of this business.
Access Urgent is an urgent care center at 233 Calhoun St with a 4.9 Google rating from 879 reviews. It is open daily from 8 am to 8 pm and accepts walk-ins, although appointments are also listed. Google attributes include on-site services, restrooms, and wheelchair-accessible parking and entrance, plus free and paid parking options. Reviewers mention fast visits, and one describes stitches and dressing done in under 45 minutes. Staff are described as warm and welcoming, and some reviewers were visitors who needed care while in town.
Best for: Walk-in urgent care with on-site services
- Address
- 233 Calhoun St, Charleston, SC 29401, United States
- Hours
- daily 8 am–8 pm
#2
Roper St. Francis Physician Partners Primary Care
★ 4.9 (511 Google reviews)Medical group
Representative photo, not of this business.
This medical group at 615 Wesley Dr in Charleston holds a 4.9 Google rating from 511 reviews. It is open Monday through Friday from 9 am to 5 pm and closed on weekends. Appointments are required or recommended, and card and NFC payments are accepted. Wheelchair-accessible parking, entrance, and restroom are listed. Reviewers mention physicians who are described as thorough and compassionate, explain decisions in plain language, and let patients speak fully during visits.
Best for: Appointment-based primary care
- Address
- 615 Wesley Dr Ste. 200, Charleston, SC 29407, United States
- Hours
- Fri 9 am–5 pm; Mon 9 am–5 pm; Sat Closed; Sun Closed; Thu 9 am–5 pm; Tue 9 am–5 pm; Wed 9 am–5 pm
#3
HCA CareNow - Mt. Pleasant
★ 4.8 (2,777 Google reviews)Urgent care center
Representative photo, not of this business.
HCA CareNow in Mount Pleasant is an urgent care center at 2863 N Hwy 17 with a 4.8 Google rating from 2,777 reviews. It is open daily from 8 am to 8 pm and accepts walk-ins. Listed services include X-ray, pediatric care, and IV therapy, and reviewers describe checking in online. Reviewers praise the attentive staff and capable nurses who cleaned and dressed a wound. Others report that registration felt long and the check-in wait was lengthy.
Best for: Urgent care with X-ray and IV therapy
- Address
- 2863 N Hwy 17, Mt Pleasant, SC 29466, United States
- Hours
- daily 8 am–8 pm
#4
Renew Medical IV Spa and Wellness
★ 5 (205 Google reviews)Wellness center
Representative photo, not of this business.
Renew Medical IV Spa and Wellness is a wellness center on the second floor at 442 King St, open daily from 10 am to 6 pm. It holds a 5 Google rating from 205 reviews. The listing notes gender-neutral toilets, card and NFC payments, and free and paid parking nearby. Reviewers mention a nurse practitioner who listens and looks at the full picture, same-day visits for people who felt unwell, and a building described as very clean and peaceful. Some visitors come for IV treatments after dehydration or heavy training.
Best for: IV treatments and same-day wellness visits
- Address
- 442 King St 2nd Floor, Charleston, SC 29403, United States
- Hours
- daily 10 am–6 pm
#5
Prisma Health Urgent Care–Mount Pleasant North
★ 4.9 (303 Google reviews)Urgent care center
Representative photo, not of this business.
This urgent care at 1101 Greythorne Dr in Mount Pleasant is open daily from 8 am to 8 pm and has a 4.9 Google rating from 303 reviews. Appointments are required, and card, debit, and NFC payments are accepted. Wheelchair-accessible parking, entrance, and restroom are listed. Reviewers mention a clean, newer facility, a friendly front desk team, and a doctor who helped with a painful cyst. One family noted their child enjoyed the front office staff.
Best for: Newer urgent care with online booking
- Address
- 1101 Greythorne Dr, Mt Pleasant, SC 29466, United States
- Hours
- daily 8 am–8 pm
How we made this list
We looked at 27 clinics in Downtown, Charleston SC with a Google rating of 4.0 or higher and at least 20 reviews, then ranked by Google rating, weighted by how many people left one. A rating from thousands of reviews counts for more than the same rating from a handful, so a new place with a few perfect scores does not jump the queue. Ratings and hours are from public Google listings on 11 October 2026 and can change. Nobody paid to be on this list.
Tips before you go
- For an early start, Access Urgent opens at 8 am.
- Hours and prices come from Google listings and change, so check the listing before a long trip.
Frequently asked questions
Which is the highest-rated clinic on this list?
Access Urgent ranks first, with a Google rating of 4.9 from 879 reviews. Roper St. Francis Physician Partners Primary Care is second at 4.9 from 511 reviews.
Which clinics in Downtown, Charleston SC are open late?
None of these stays open past midnight. The latest to close is Access Urgent, at 8 pm.
Which of these have free parking?
Google lists free parking for Access Urgent and Renew Medical IV Spa and Wellness.
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