5 Best Clinics in Downtown, Knoxville TN
Updated 11 October 2026 · 30 clinics in Downtown, Knoxville TN considered · Ranked from Google ratings
This list gathers the best-rated clinic and urgent care businesses for the Downtown Knoxville, TN area, ordered by Google rating weighted by review count. It is useful for anyone who needs same-day care, a walk-in visit or a routine service near the center of Knoxville. Thirty qualifying businesses were considered. Some listings sit outside the immediate downtown core, so each entry shows its own address for checking.
#1
Downtown Smooth Spa
★ 5 (655 Google reviews)Day spa
Representative photo, not of this business.
Downtown Smooth Spa is a day spa at 107 Main St SW, Suite 200, with a 5 Google rating from 655 reviews. Listed hours vary through the week, with Monday and Sunday closed and Saturday hours ending at 3:30 pm. The listing notes wheelchair-accessible parking, entrance, seating and toilet. Reviewers mention facial and hydrafacial treatments, a relaxing atmosphere, skilled staff and a clean, welcoming space. It is listed as a spa rather than a medical clinic.
Best for: Facials and hydrafacial appointments downtown
- Address
- 107 Main St SW #200, Knoxville, TN 37902, United States
- Hours
- Fri 9 am–5 pm; Mon Closed; Sat 8:30 am–3:30 pm; Sun Closed; Thu 9 am–5 pm; Tue 9 am–5 pm; Wed 10 am–6 pm
#2
AFC Urgent Care Powell
★ 4.9 (985 Google reviews)Urgent care center
Representative photo, not of this business.
AFC Urgent Care Powell is an urgent care center at 233 E Emory Rd, Suite 111, in Powell, TN, with a 4.9 Google rating from 985 reviews. Listed hours are 8 am to 8 pm Monday through Friday and 8 am to 5 pm on Saturday and Sunday. The listing notes wheelchair-accessible parking, entrance and toilet. Reviewers mention friendly staff, quick visits after other clinics were too busy, and providers who listened closely. One reviewer says the clinic called back to check on them.
Best for: Weekend walk-in urgent care
- Address
- 233 E Emory Rd Suite 111, Powell, TN 37849, United States
- Hours
- Fri 8 am–8 pm; Mon 8 am–8 pm; Sat 8 am–5 pm; Sun 8 am–5 pm; Thu 8 am–8 pm; Tue 8 am–8 pm; Wed 8 am–8 pm
#3
Covenant Health Urgent Care - South Knoxville
★ 4.9 (781 Google reviews)Urgent care center
Representative photo, not of this business.
Covenant Health Urgent Care - South Knoxville is an urgent care center at 7625 Chapman Hwy, Suite 107, with a 4.9 Google rating from 781 reviews. Listed hours are 8 am to 8 pm every day. The listing notes wheelchair-accessible parking, entrance and toilet. Reviewers mention a professional medical assistant, a Sunday visit, a helpful front desk, and a same-day visit for a thumb injury when a primary doctor had no openings. Some describe the imaging department as excellent.
Best for: Daily urgent care with imaging on site
- Address
- 7625 Chapman Hwy #107, Knoxville, TN 37920, United States
- Hours
- daily 8 am–8 pm
#4
AFC Urgent Care Chapman Highway TN
★ 4.8 (2,358 Google reviews)Urgent care center
Representative photo, not of this business.
AFC Urgent Care Chapman Highway TN is an urgent care center at 7564 Chapman Hwy with a 4.8 Google rating from 2,358 reviews. Listed hours are 8 am to 8 pm Monday through Friday and 8 am to 5 pm on Saturday and Sunday. The listing notes wheelchair-accessible parking, entrance, seating and toilet. Reviewers mention online registration, a clean waiting area, attentive reception and providers, careful care for a child with an eye injury, and quick injections. Some travel a long way to visit.
Best for: Online check-in and family urgent visits
- Address
- 7564 Chapman Hwy, Knoxville, TN 37920, United States
- Hours
- Fri 8 am–8 pm; Mon 8 am–8 pm; Sat 8 am–5 pm; Sun 8 am–5 pm; Thu 8 am–8 pm; Tue 8 am–8 pm; Wed 8 am–8 pm
#5
Urgent Team Walk-in Urgent Care - Knoxville
★ 4.8 (1,415 Google reviews)Urgent care center
Representative photo, not of this business.
Urgent Team Walk-in Urgent Care - Knoxville is an urgent care center at 6942 Maynardville Pike with a 4.8 Google rating from 1,415 reviews. Listed hours are 8 am to 8 pm Monday through Friday and 8 am to 4 pm on Saturday and Sunday. The listing notes wheelchair-accessible parking, entrance and toilet. Reviewers mention Saturday visits when a regular doctor was not available, a knowledgeable intake nurse, a courteous receptionist, and a doctor who explained options and medication choices clearly.
Best for: Walk-in visits when your doctor is booked
- Address
- 6942 Maynardville Pike, Knoxville, TN 37918, United States
- Hours
- Fri 8 am–8 pm; Mon 8 am–8 pm; Sat 8 am–4 pm; Sun 8 am–4 pm; Thu 8 am–8 pm; Tue 8 am–8 pm; Wed 8 am–8 pm
How we made this list
We looked at 30 clinics in Downtown, Knoxville TN with a Google rating of 4.0 or higher and at least 20 reviews, then ranked by Google rating, weighted by how many people left one. A rating from thousands of reviews counts for more than the same rating from a handful, so a new place with a few perfect scores does not jump the queue. Ratings and hours are from public Google listings on 11 October 2026 and can change. Nobody paid to be on this list.
Tips before you go
- For an early start, AFC Urgent Care Powell opens at 8 am.
- Hours and prices come from Google listings and change, so check the listing before a long trip.
Frequently asked questions
Which is the highest-rated clinic on this list?
Downtown Smooth Spa ranks first, with a Google rating of 5 from 655 reviews. AFC Urgent Care Powell is second at 4.9 from 985 reviews.
Which clinics in Downtown, Knoxville TN are open late?
None of these stays open past midnight. The latest to close is AFC Urgent Care Powell, at 8 pm.
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