5 Best Pharmacies in Downtown, Iowa City IA
Updated 11 October 2026 · 6 pharmacies in Downtown, Iowa City IA considered · Ranked from Google ratings
This list covers pharmacies in the Downtown Iowa City, IA area, drawn from Google listings and public reviews. Six qualifying businesses were considered. Each is ranked by Google rating, weighted by the number of reviews, so a strong score backed by many reviews ranks above a perfect score with few. The list is meant to help readers compare hours, pickup and delivery options, and the kind of customer service described in reviews. It is not medical advice, so confirm details with each pharmacy before a visit.
#1
Towncrest Wellness Apothecary
★ 5 (60 Google reviews)Pharmacy
Representative photo, not of this business.
Towncrest Wellness Apothecary is a pharmacy on South 1st Avenue South, rated 5 from 60 Google reviews. Its weekday hours include a midday break, and it is closed on weekends. Google lists wheelchair-accessible parking and entrance. Reviewers mention nutrition advice, feedback on vitamins and supplements, and over-the-counter skincare products. Some value prescriptions mailed to them and reminder calls about refills, while others describe GLP-1 and hormone therapy support.
Best for: Wellness-focused pharmacy with mailed refills
- Address
- 901 S 1st Ave South, Iowa City, IA 52240, United States
- Hours
- Fri 8:30 am–12:30 pm, 1–5:30 pm; Mon 8:30 am–12:30 pm, 1–5:30 pm; Sat Closed; Sun Closed; Thu 8:30 am–12:30 pm, 1–5:30 pm; Tue 8:30 am–12:30 pm, 1–5:30 pm; Wed 8:30 am–12:30 pm, 1–5:30 pm
#2
Iowa River Landing Pharmacy
★ 4.9 (60 Google reviews)Pharmacy
Representative photo, not of this business.
Iowa River Landing Pharmacy is listed on East 9th Street in Coralville, IA, rated 4.9 from 60 Google reviews. Weekday hours run into the evening, with a short Saturday morning window and Sunday closed. Google lists wheelchair-accessible parking and entrance. Reviewers mention fast service and friendly pharmacists and technicians. One reviewer says an out-of-stock medication was obtained from another location the same day, and parking spaces are described as roomy.
Best for: Fast fills with spacious parking
- Address
- 105 E 9th St A, Coralville, IA 52241, United States
- Hours
- Fri 8 am–5:30 pm; Mon 8 am–8 pm; Sat 8:30 am–12:30 pm; Sun Closed; Thu 8 am–8 pm; Tue 8 am–8 pm; Wed 8 am–8 pm
#3
Hy-Vee Drugstore
★ 4.4 (306 Google reviews)Pharmacy
Representative photo, not of this business.
Hy-Vee Drugstore on North 1st Avenue is rated 4.4 from 306 Google reviews. Weekday hours split into midday and afternoon windows, Saturday closes at 3 pm and Sunday is closed. Google lists wheelchair-accessible parking, entrance, seating and toilet. Reviewers praise the garden center and the store staff, and one says pharmacy staff made sure they understood their pickup. Other reviewers report poor phone service and a strict pickup window at closing time.
Best for: Garden center and in-store pharmacy
- Address
- 310 N 1st Ave, Iowa City, IA 52245, United States
- Hours
- Fri 10 am–2 pm, 2:30–7 pm; Mon 10 am–2 pm, 2:30–7 pm; Sat 9 am–3 pm; Sun Closed; Thu 10 am–2 pm, 2:30–7 pm; Tue 10 am–2 pm, 2:30–7 pm; Wed 10 am–2 pm, 2:30–7 pm
#4
Hy-Vee
★ 4.6 (27 Google reviews)Grocery store
Representative photo, not of this business.
Hy-Vee at 310 North 1st Avenue is a grocery store that shares its address with a pharmacy on this list. It is open daily from 7 am to 9 pm, and it is rated 4.6 from 27 Google reviews. Google lists wheelchair-accessible parking, entrance and toilet. Reviewers describe the store as well stocked and mention a large garden selection with many accessories. One reviewer says the staff stayed helpful on a hard day.
Best for: Garden supplies and everyday groceries
- Address
- 310 N 1st Ave, Iowa City, IA 52245, United States
- Hours
- daily 7 am–9 pm
#5
Towncrest Pharmacy
★ 4.4 (47 Google reviews)Pharmacy
Representative photo, not of this business.
Towncrest Pharmacy on Muscatine Avenue is rated 4.4 from 47 Google reviews. It is open weekdays until 5:30 pm and Saturday until noon, and it is closed Sunday. Google lists wheelchair-accessible parking and entrance. Reviewers describe friendly, caring staff and a range of medical supplies. Some say they switched after closures and delays elsewhere. One notes the pharmacy does not accept GoodRx pricing, and others find limited hours and an app that did not match ready prescriptions hard to work with.
Best for: Caring local service with medical supplies
- Address
- 2306 Muscatine Ave #100, Iowa City, IA 52240, United States
- Hours
- Fri 8:30 am–5:30 pm; Mon 8:30 am–5:30 pm; Sat 9 am–12 pm; Sun Closed; Thu 8:30 am–5:30 pm; Tue 8:30 am–5:30 pm; Wed 8:30 am–5:30 pm
How we made this list
We looked at 6 pharmacies in Downtown, Iowa City IA with a Google rating of 4.0 or higher and at least 20 reviews, then ranked by Google rating, weighted by how many people left one. A rating from thousands of reviews counts for more than the same rating from a handful, so a new place with a few perfect scores does not jump the queue. Ratings and hours are from public Google listings on 11 October 2026 and can change. Nobody paid to be on this list.
Tips before you go
- For an early start, Hy-Vee opens at 7 am.
- Hours and prices come from Google listings and change, so check the listing before a long trip.
Frequently asked questions
Which is the highest-rated pharmacy on this list?
Towncrest Wellness Apothecary ranks first, with a Google rating of 5 from 60 reviews. Iowa River Landing Pharmacy is second at 4.9 from 60 reviews.
Which pharmacies in Downtown, Iowa City IA are open late?
None of these stays open past midnight. The latest to close is Hy-Vee, at 9 pm.
Run a business in Downtown?
Get a fast website with your hours, menu, location and reviews. If your business is listed here and something is wrong, tell us and we fix it.
Email support@pagenearby.com