5 Best Clinics in Downtown, Durham NC
Updated 11 October 2026 · 19 clinics in Downtown, Durham NC considered · Ranked from Google ratings
This guide covers clinics and urgent care centers that appear in searches for Downtown Durham NC, ranked by Google rating and weighted by how many people reviewed each one. Nineteen qualifying businesses were considered. Several listed clinics sit outside downtown itself, in Lowes Grove, Spring Forest, Midtown Raleigh and Wake Forest, so check the address and hours before you travel. This is general information only and not medical advice. For emergencies, call 911.
#1
WakeMed MyCare 365 Primary & Urgent Care - Lowes Grove
★ 4.9 (448 Google reviews)Urgent care center
Representative photo, not of this business.
Urgent care center at 2216 NC-54 in Durham, rated 4.9 from 448 reviews. It is open weekdays from 8 am to 8 pm and on weekends from 8 am to 4 pm. Google lists wheelchair-accessible parking, entrance and toilet. Reviewers mention a caring, attentive team, a smooth check-in, and a provider who answered every question before the visit ended. Reviewers also describe the facility as clean and organized.
Best for: Patients who want an unhurried visit
- Address
- 2216 NC-54, Durham, NC 27713, United States
- Hours
- Fri 8 am–8 pm; Mon 8 am–8 pm; Sat 8 am–4 pm; Sun 8 am–4 pm; Thu 8 am–8 pm; Tue 8 am–8 pm; Wed 8 am–8 pm
#2
WakeMed MyCare 365 Primary & Urgent Care - Spring Forest
★ 4.8 (891 Google reviews)Urgent care center
Representative photo, not of this business.
Primary and urgent care at 815 Springfield Commons Dr in Raleigh, rated 4.8 from 891 reviews. Hours are weekdays 8 am to 8 pm and weekends 8 am to 4 pm. Google lists wheelchair-accessible parking, entrance and toilet. Reviewers mention a friendly front desk, quick intake for new patients, and clinicians who offered ideas without judgment. One reviewer said the clinic had no tablets for intake that day, which slowed paperwork.
Best for: New patients needing primary or urgent care
- Address
- 815 Springfield Commons Dr, Raleigh, NC 27609, United States
- Hours
- Fri 8 am–8 pm; Mon 8 am–8 pm; Sat 8 am–4 pm; Sun 8 am–4 pm; Thu 8 am–8 pm; Tue 8 am–8 pm; Wed 8 am–8 pm
#3
AFC Urgent Care Raleigh Midtown
★ 4.7 (2,011 Google reviews)Urgent care center
Representative photo, not of this business.
Urgent care center at 2913 Wake Forest Rd in Raleigh, rated 4.7 from 2,011 reviews. It accepts walk-ins, with weekday hours from 8 am and weekend hours ending at 5 pm. Google lists online care, IV therapy, X-ray, pediatric care and free parking. Reviewers mention a clean facility that does not feel like a typical doctor's office, quick visits for ear infections and strep throat, and easy online booking.
Best for: Same-day care for common illnesses
- Address
- 2913 Wake Forest Rd, Raleigh, NC 27609, United States
- Hours
- Fri 8 am–8 pm; Mon 8 am–8 pm; Sat 8 am–5 pm; Sun 8 am–5 pm; Thu 8 am–8 pm; Tue 8 am–8 pm; Wed 8 am–3:30 pm
#4
EmergeOrtho Durham
★ 4.7 (1,913 Google reviews)Orthopedic clinic
Representative photo, not of this business.
Orthopedic clinic at 120 William Penn Plaza in Durham, rated 4.7 from 1,913 reviews. It is open daily from 8 am to 8 pm, and appointments are recommended. Google lists on-site parking, a wheelchair-accessible entrance and toilet, and card or mobile payment. Reviewers mention a bone scan done with care, staff who helped a nervous child, and a physician who explained treatment clearly. One reviewer reported being turned away from urgent care over an old balance.
Best for: Bone and joint concerns with booking
- Address
- 120 William Penn Plaza, Durham, NC 27704, United States
- Hours
- daily 8 am–8 pm
#5
WakeMed MyCare 365 Primary & Urgent Care - Wake Forest
★ 4.7 (1,432 Google reviews)Urgent care center
Representative photo, not of this business.
Urgent care and primary care at 2001 S Main St in Wake Forest, rated 4.7 from 1,432 reviews. Hours are weekdays 8 am to 8 pm and weekends 8 am to 4 pm. Google lists wheelchair-accessible parking, entrance and toilet. Reviewers mention a fast visit with a warm nurse, a clinician who diagnosed a problem quickly, and exams for commercial driver's licenses. Some say weekend appointments help people who cannot take time off on weekdays.
Best for: Weekend visits and CDL medical exams
- Address
- 2001 S Main St #200, Wake Forest, NC 27587, United States
- Hours
- Fri 8 am–8 pm; Mon 8 am–8 pm; Sat 8 am–4 pm; Sun 8 am–4 pm; Thu 8 am–8 pm; Tue 8 am–8 pm; Wed 8 am–8 pm
How we made this list
We looked at 19 clinics in Downtown, Durham NC with a Google rating of 4.0 or higher and at least 20 reviews, then ranked by Google rating, weighted by how many people left one. A rating from thousands of reviews counts for more than the same rating from a handful, so a new place with a few perfect scores does not jump the queue. Ratings and hours are from public Google listings on 11 October 2026 and can change. Nobody paid to be on this list.
Tips before you go
- For an early start, WakeMed MyCare 365 Primary & Urgent Care - Lowes Grove opens at 8 am.
- Hours and prices come from Google listings and change, so check the listing before a long trip.
Frequently asked questions
Which is the highest-rated clinic on this list?
WakeMed MyCare 365 Primary & Urgent Care - Lowes Grove ranks first, with a Google rating of 4.9 from 448 reviews. WakeMed MyCare 365 Primary & Urgent Care - Spring Forest is second at 4.8 from 891 reviews.
Which clinics in Downtown, Durham NC are open late?
None of these stays open past midnight. The latest to close is WakeMed MyCare 365 Primary & Urgent Care - Lowes Grove, at 8 pm.
Which of these have free parking?
Google lists free parking for AFC Urgent Care Raleigh Midtown.
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